Segmentation maps a logical address (a 16-bit selector plus a 32-bit offset) to a 32-bit linear address, enforcing privilege and limit checks along the way. Paging then translates that linear address to a physical address, adding a second layer of User/Supervisor and Read/Write protection. The two layers are independent: segmentation is always active in protected mode, while paging is optional (controlled by CR0.PG).
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从1994年 FGFR3靶点被证实与ACH相关，到2021年Vosoritide获批上市，ACH患者等待了近30年，才迎来首款针对性治疗药物。而随着Infigratinib叩响上市的大门，以及身后一众迭代疗法的逼近，ACH精准治疗的新大门正加速开启。这也是罕见病从被行业忽略到逐渐被重视的真实缩影。
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